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Statin Drug Efficacy (SREBF2, drug side effects)

Cardiology 04.028

Statin Drug Efficacy (SREBF2, drug side effects)

PHGN
Signs/symptoms: A595G: risk factor for atherosclerosis and coronary artery disease (Atherosclerosis 2002;164:15) (PCT patent 02280, US patent / EU patent pending)
Complications:
Early diagnosis/treatment: Yes

Material required:
Blood tubes: EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush: Yes
Chromosomal localization: 22q13 OMIM number: 600481

Sterol-regulatory element-binding protein-2

SREBF2

Gene regions tested:
Gene regions:
Amino acid positions: A595G
Nucleotide positions:
Test methods: Restriction Fragment Length

Prices:

Switzerland:
8820.00 8811.01 8818.00
  TP REVAL: 350 TP Value: 0.9 CHF 315.00
Other europe: EUR 215.00
Other regions: USD call

References:
Miserez AR, Muller PY, Barella L, Barella S, Staehelin HB, Leitersdorf E, Kark JD, Friedlander Y. Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia. Atherosclerosis. 2002;164:15-26.
Muller, P. Y.; Miserez, A. R. Identification of mutations in the gene encoding sterol regulatory element binding protein (SREBP)-2 in hypercholesterolaemic subjects. J. Med. Genet. 39: 271-275, 2002.

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