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Alzheimer Dementia, sporadic, association marker A2M |
AD2 |
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Signs/symptoms: |
Dementia, late onset, sporadic |
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Complications: |
Neuritic plaques and neurons with neurofibrillary tangles. |
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Early diagnosis/treatment: |
Yes |
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Association between a deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene and Alzheimer's disease (AD). |
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Material required: |
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Blood tubes: |
EDTA whole blood (do not freeze, do not centrifugate) |
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Mouth brush: |
Yes |
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Chromosomal localization: |
12p13.3-p12.3 |
OMIM number: |
103950 |
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Alpha-2 macroglobulin |
A2M |
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Gene regions tested: |
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Gene regions: |
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Amino acid positions: |
V1000I |
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Nucleotide positions: |
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Test methods: |
Sequencing |
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TP REVAL: |
250 |
TP Value: |
0.9 |
CHF |
225.00 |
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Other europe: |
EUR |
160.00 |
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Other regions: |
USD |
call |
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| Matthijs, G.; Marynen, P. A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene. Nucleic Acids Res. 19: 5102, 1991. | |
| Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, Staehelin H, Growdon JH, Tanzi RE, Hyman BT. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Hum Mol Genet. 1998;7:1953-1956. | |
| Zappia M, Manna I, Serra P, Cittadella R, Andreoli V, La Russa A, Annesi F, Spadafora P, Romeo N, Nicoletti G, Messina D, Gambardella A, Quattrone A. Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms. Arch. Neurol. 61:341-344,2004. | |
