Frontotemporal Dementia, Pick disease (sequence of exons 9-13)

Neurology

10.023

Frontotemporal Dementia, Pick disease (sequence of exons 9-13)

FTDP

Signs/symptoms:	Dementia, early onset, familial, autosomal dominant.
Complications:	Microtubule-associated protein tau.
Early diagnosis/treatment:	Yes

Dementia, frontotemporal with or without Parkinsonism, Pick disease. Mutations reduce the ability of tau to bind microtubules and to promote microtubule assembly.

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	No

Chromosomal localization:

17q21.1

OMIM number:

600274

Microtubule-associated protein tau (sequence of exons 9-13)

MAPT

Gene regions tested:
Gene regions:	exons 9-13
Amino acid positions:
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	2400	TP Value:	0.9	CHF	2160.00
Other europe:	EUR					1500.00
Other regions:	USD					call

References:

Goedert M, Spillantini MG. A century of Alzheimer's disease. Science. 2006;314:777-781.

Rademakers R, Cruts M, van Broeckhoven C. The role of tau (MAPT) in frontotemporal dementia and related tauopathies. Hum. Mutat. 2004;24:277-295.

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Frontotemporal Dementia, Pick disease (sequence of exons 9-13)