Alzheimer Dementia, sporadic, association marker CSTD

Geriatry

13.006

Alzheimer Dementia, sporadic, association marker CSTD

AD2

Signs/symptoms:	Dementia, late onset, sporadic
Complications:	Neuritic plaques and neurons with neurofibrillary tangles.
Early diagnosis/treatment:	Yes

Association between the cathepsin D polymorphism and neurodegenerative disorders.

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

11p15.5

OMIM number:

116840

Cathepsin D (lysosomal aspartyl protease) (association marker)

CTSD

Gene regions tested:
Gene regions:
Amino acid positions:	A224V
Nucleotide positions:
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	250	TP Value:	0.9	CHF	225.00
Other europe:	EUR					160.00
Other regions:	USD					call

References:

Papassotiropoulos A, Bagli M, Feder O, Jessen F, Maier W, Rao ML, Ludwig M, Schwab SG, Heun R. Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease. Neurosci Lett. 1999;262:171-174.

Steinfeld, R.; Reinhardt, K.; Schreiber, K.; Hillebrand, M.; Kraetzner, R.; Bruck, W.; Saftig, P.; Gartner, J. Cathepsin D deficiency is associated with a human neurodegenerative disorder. Am. J. Hum. Genet. 78: 988-998, 2006.

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Alzheimer Dementia, sporadic, association marker CSTD