Alzheimer Dementia, sporadic, association marker MPO

Geriatry

13.010

Alzheimer Dementia, sporadic, association marker MPO

AD2

Signs/symptoms:	Dementia, late onset, sporadic
Complications:	Neuritic plaques and neurons with neurofibrillary tangles.
Early diagnosis/treatment:	Yes

Promoter polymorphism within an Alu-encoded hormone response element in the MPO gene. The G allele is associated with stronger promoter activity and gene expression, whereas the A allele creates a binding site for a nuclear factor or receptor. The G/G genotype is the most common.

Material required:
Blood tubes:	EDTA whole blood (do not freeze, do not centrifugate)
Mouth brush:	Yes

Chromosomal localization:

17q23.1

OMIM number:

606989

Myeloperoxidase (association marker)

MPO

Gene regions tested:
Gene regions:
Amino acid positions:
Nucleotide positions:	nt(-463)G to A
Test methods:	Sequencing

Prices:

Switzerland:

8820.00

8811.01

8819.01

	TP REVAL:	250	TP Value:	0.9	CHF	225.00
Other europe:	EUR					160.00
Other regions:	USD					call

References:

Crawford FC, Freeman MJ, Schinka JA, Morris MD, Abdullah LI, Richards D, Sevush S, Duara R, Mullan MJ. Association between Alzheimer's disease and a functional polymorphism in the Myeloperoxidase gene. Exp Neurol. 2001;167:456-459.

Zappia, M.; Manna, I.; Serra, P.; Cittadella, R.; Andreoli, V.; La Russa, A.; Annesi, F.; Spadafora, P.; Romeo, N.; Nicoletti, G.; Messina, D.; Gambardella, A.; Quattrone, A. Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms. Arch. Neurol. 61: 341-344, 2004.

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Alzheimer Dementia, sporadic, association marker MPO